WILLIAM H. TALIAFERRO 



697 



the accumulation of the parasites. Their experiments are in accord with the work of 

 Bass and Johns (191 2) and others who have found sugar necessary for the cultivation 

 of the malarial organisms outside of the body and with the results of Bass and Johns 

 (1913) who succeeded in cultivating the parasites in the blood from a case of diabetes 

 without the addition of sugar. Although a great deal more work is needed, it would 

 seem likely in view of all this work that the decrease of blood sugar so injures the 

 parasite or parasite-red-cells combination that it is phagocyted. 



lopoo 



«o 



1000 



sioo 



-S 10 



E 



/^Tiiro ifirds injected I.V luifb parasites :- 

 -^ , one bird had been infected 45 ddy5 



prsviousl^ other bird normal 



_ ''mantAl Bird 



I 2 3 4 5 6 7 S 9 



Da/^s after Experiment. 



Fig. II. — Experiment showing the disappearance of washed parasitized cells from the blood of 

 a bird in the latent infection and the survival of the same type of cells in a control uninfected bird. 

 Both birds (one with latent infection and the other uninfected) were injected intravenously with 

 enough washed infected cells so that a few minutes later both showed an infection of about eight 

 parasites per ten thousand red cells. In the bird with the latent infection these were removed from 

 the circulation within twelve hours, but in the uninfected bird they survived and progressively 

 increased in numbers. 



The failure to find an antibody basis for the destruction of the parasites in birds 

 suggests the same lack of antibody basis in man, but one hesitates to draw too close 

 a parallelism because no anti-malarial antibodies of any type have been found in the 

 bird whereas they have been found in man. Thus, Maldovan (1912) failed to obtain 

 any evidence of protective or complement-fixing antibodies in the avian infection. 

 This has been corroborated by the present author (unpublished work), who m addi- 

 tion found no evidence of a lytic antibody. Fisher (unpublished work) could not 

 demonstrate precipitins. In human malaria, however, both complement-fixing anti- 

 bodies and precipitins have been demonstrated. (For a review of the literature see 

 the author, L. G. Taliaferro, and Fisher [1927]). Furthermore, the results on 



