698 INFECTION BY THE BLOOD PROTOZOA 



the relation of sugar to the human infection are rather inconclusive. Working with 

 induced benign tertian malaria in general paresis, Rudolf and Marsh (1927) found 

 glycosuria in a higher percentage of cases of general paresis treated with malaria than 

 untreated. (Also see their paper for a review of previous work on the same subject.) 

 During the induced malaria the blood sugar varied inversely as the temperature, 

 although it may be higher after the fall in temperature than before pyrexia. Ad- 

 ministration of glucose gave no effects on objective symptoms nor parasites but ap- 

 parently relieved subjective symptoms. Administration of insulin produced indefinite 

 results, but in 60 per cent of the cases the fever terminated after administration, and 

 although relapses followed, they were of a lower degree of pyrexia than those follow- 

 ing quinine therapy. They also conclude that lowering the blood sugar does not 

 appear to be the cause of the cessation of the fever. In all this work there is the possi- 

 bility that a diminution of the blood sugar is a concomitant change rather than the 

 basis for the disappearance of the parasites. Thus, in trypanosome infections where 

 there is so much evidence for the role of antibodies there may be profound changes 

 in the blood sugar. (For a review of some of this work see Regendanz and Tropp 

 1927].) 



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