738 HETEROPHILE ANTIGENS AND ANTIBODIES 



necessary. If the complex is disrupted neither fraction gives rise to antibody produc- 

 tion. In test tube reactions, however, only the lipoid fraction is necessary, the protein 

 fraction apparently not taking part in these reactions. 



The pathological effects of heterophile-immune serum, at least for guinea pigs, are 

 very much like those of anaphylactic shock, but certain essential differences have been 



pointed out. 



In obtaining serological reactions with any kind of tissues, or extracts from them, 

 the presence or absence of heterophile antigen must come into consideration. 



