FREDERICK P. GAY 891 



another (Lewis and Lewis', Maximow,^ Eliot^). A change in function accompanies 

 the change as demonstrated by the reaction to certain dyestuffs. It is still an open 

 question whether the connection between endothelium and histiocytes is equally 

 direct.4 Recent evidence by Fried^ would indicate that the so-called "alveolar epi- 

 thelial cells" of the lungs give rise to the phagocytic cells in inflammatory process of 

 that organ. 



It may well be that we shall eventually trace all the fundamental immunity 

 processes to one or another of that group of differentiated cells which we collect 

 loosely under the designation of "reticulo-endothelial system." Antibody formation 

 relatively great resistance, ultimate disposal — not only of bacteria but of polymorpho- 

 nuclears that have already ingested bacteria — we tentatively refer to them. With 

 our attention finally directed in the right direction, progress in immunology should 

 take a new step forward. 



' Lewis, M. R. and W. H.: Pub. Carnegie Inst, of Washington, No. 363. 1927. 



^^ Maximow, A.: Proc. Soc. Exper. Biol. &° Med., 24, 570. 1927. 



5 Eliot, C: Bull. Johns Hopkins Hasp., 39, 149. 1926. 



"Mallory, F. B.: /. Exper. Med., 3, 611. 1898. 



5 Fried, B. M.: Arch. Path, df Lab. Med., 3, 751. 1927. 



