iioo NON-SPECIFIC PROTEIN THERAPY 



On the other hand the cerebro-spinal fluid shows such an increase in paresis during 

 the malarial paroxysm, but not following a milk injection. This lends support to the 

 presumption that a focal reaction takes place at the site of the lesion during the 

 malarial reaction/'- and is in accord with the findings of Straussler and Koskinas/ 

 who have demonstrated increased inflammatory reactions during the malarial fever. 



SUMMARY 



The parenteral administration of foreign substances (bacteria, serum, milk, etc.) 

 is followed by a diphasic reaction of the organism. This reaction involves a complex 

 biological re-orientation, demonstrable with physical and chemical changes in the 

 blood and tissues, with changes in the reactivity of the central and vegetative nervous 

 system, in secretory glands, in lymph and blood capillaries, in the reticulo-endothelial 

 system, in the leukocytes, and in the antibody mechanism. Usually the injection of 

 a non-specific agent *o followed by a diphasic clinical alteration — first intensification 

 of symptoms followed by diminution. At the site of a local inflammatory lesion a 

 focal reaction takes place. The therapeutic effect of the protein injection is to be 

 sought in definite and long-persisting alterations in certain of the cell membranes of 

 the body, in contradistinction to ordinary pharmacological effects which seem to de- 

 pend on relatively transient alterations of the physical state of cells or cell groups. 



'Nonne, M.: Med. KL, 25, 1825. 1925. 



^ Reese, H., and Peter, K.: ibid., 24, 37. 1924. 



3 Straussler, E., and Koskinas, G.: Miinch. med. Wchr., 70, 783. 1923. 



