646 



the fate of arsenic in the body. 

 Table 5. 



Time 



after 



Dosing. 



First day 

 Second ,, 

 Third ,, 

 Fourth ,, 

 Fifth 



Sixth ,, 

 Seventh ,, 

 Eighth ,, 



Total in 8 days 



Sheep : Weight 40 Kilos. 



Dosed with sodium arsenite 



equivalent to 02 gm. AsjO^, 



in rice-dough ball. 



Horse : Weight 390 Kilos. 



Total AS2O3 in 



Urine. 



Gram. 

 •023 



•071 



•038 



•013 



•0061 



•0034 



•0025 



•COlO 



) -158 

 ( == 79% 



Faeces. 



Gram, 

 trace 



■0059 



•OIU 



•0035 



•0029 



•0021 



•0015 



•0009 



•028 



- 14% 



Dosed with sodium arsenite 



equivalent to 2.0 gm. As.^0., 



in rice-dough ball. 



Total AsjOy in 



Urine. 



Gram. 

 •026 



•124 



•135 



•008 



•035 



■021 



•Oil 



•C05 



•445 

 = 23% 



Fteces. 



Gram. 

 ■008 



•061 



•981 



slight 

 diarrhoea 



•085 



048 



•003 



1186 

 = 59% 



Together 



93% of the dose 



82% of the dose 



It will be noted that for the sheep the elimination of arsenic 

 in the urine rises for the first 48 hours, then diminishes until at 

 the end of eight days it is down to i milligram for the whole 

 24 hours' output. By this time 93 per cent, of the dose has been 

 excreted, of which 79 per cent, appears in the urine and 14 per 

 cent, in the faeces. With the horse on the other hand, the greater 

 part of the dose has been eliminated in the faeces ; 23 per cent, in 

 the urine and 59 per cent, in the faeces, together accounting for 

 82 per cent, of the dose. Whether the remaining 18 per cent, 

 unaccounted for is still present in the body, or is largely attribut- 

 able to experimental error, cannot be stated. The margin of error 

 in such " balance experiments " is often considerable. 



The behaviour of the horse is interesting and rather un- 

 expected. The data for the sheep are undoubtedly representa- 

 tive since they are amply confirmed by similar results, published 

 b}'' one of us in another connection (/. c, i). A priori, one would 

 have expected the major proportion of soluble arsenite adminis- 

 tered to the horse to have been also eliminated in the urine, and 



