THE FATE OF ARSENIC IN THE BODY. 



649 



that by the blood low, and by brain, nerve, and bone very low 

 indeed. 



A point of special interest is the fact that although the 

 arsenic was injected straight into the blood-stream, small but 

 easily detected quantities appear in the faeces, thus pointing either 

 to a slight intestinal-hepatic circulation or to slight endosmosis 

 from the mesenteric blood; or to both. 



In regard to the projx>rtion of the injected arsenic which 

 is recovered in the tissues analysed, it is probable that the balance 

 unaccounted for is distributed over the tissues not examined,, 

 which still amount to alxjut one-fifth of the body weight. A fair 

 margin of experimental error must be allowed, however, in this 

 class of work, where a very small amount of arsenic is distribtited 

 over a very large bulk of animal tissues. The data for organs 

 such as the liver, have a much higher degree of accuracy than 

 those for muscular tissue, which cannot be properly determined 

 without inordinate labour. A mixed sample of miscellaneous 

 m.uscle is unsatisfactory, and althotigh the analytical determina- 

 tions may be made with reasonable accuracy, there is no 

 guarantee that different muscles do not vary considerably in the 

 extent of arsenic fixation. 



These data only give us information concerning the dis- 

 tribution of arsenic after intravenous injection. We hope to 

 extend the work and follow up the distribution with varying 

 closes and varying mode of entry into the body. Further dis- 

 cussion may therefore be postponed until more extensive data . 

 are acquired. 



In passing, however, the data for arsenic in the alimentary 

 tract, liver, spleen, and kidneys, of a horse destroyed by oral 

 administration of arsenic, may be given. 



Table 7. 



HoK'SE : Wei.^ht 357 Kilos. Drenched with 7'6 «m. of sodium arsenite, 

 equivalent to 6 gm. As.tO.,. Died '.) hours later. 



