-18 5 5- 



A toxic principle found in decomposing protein substances was 

 soluble in water but not in alcohol. Sterilization did not 

 alter its toxicity. In minute quantities it was capable of 

 producing fever, and the lethal dose for the dog was only 0.012 Gm, 



-1865- 



5, BILLROTH, TH. 



Beobactungstudien uber wundfieber und (accidentelle) Wundkrank- 

 heiten (Observational studies on wound fever and accidental 

 wound infections) 



Arch, f, klin. Chir. 6:372-495, I865 



Related findings were observed earlier. Fever appeared during 

 the course of injections in patients. Chemical products in the 

 medicaments were first considered to be the pyrexial agents. 

 After a rise in temperature was noted when ordinary distilled 

 water was injected, it was concluded that the solvents were 

 probably contaminated . 



-1866- 



6. FRESE, H. 



Experimente lle Beitrage zur Aetiologie des Fiebers (Experimental 

 contribution on the etiology of fevers) 



Berlin, 1866 



In decomposing tissue a soluble toxic material can be secured 

 which resists boiling and passes through filters. 



- 1 8 7 2 - 



MANASSEIN, W, 



Ueber die wasserigen und alkoholischen Extracte der Muskeln und 

 der Leber von fieberenden und hungernden Thleren (On aqueous 



