^ 



- 1 8 7 3 - 



11. ILIFPE, W. 



Remarkable oscillation of temperature without apparent cause 



Lancet 2:728, I878 



A patient without other symptoms in whom an increase or decrease 

 in body temperature appeared regularly was described. The cause 

 was not found. 



- 1 8 8 7 - 



12. VON JAUREGG, Jo WAGNER 



Ueber die Einwirking fleberhafter Erkrankungen auf Psychosen 

 (Action of fever-increasing Illnesses on psychotic patients) 



Jahrbuch fur Psychiat . Bd . 7:9^-102, I887-8 



It was noted that progressive paralysis in long-established 

 neurosyphilis appeared to improve under the stress of acute, 

 accidental Infections. The fever engendered was considered 

 , to be the curative agent. In attempting to reproduce these bene- 

 ficial results, von Jauregg utilized both crude typhoid vaccine 

 and injections of malarial parasites, in his later studies, 

 (1917). In the years between I887 and I909, he secured favorable 

 results through the use of Koch's old tuberculin. 



-1889 



13. ROUSSY, G. 



Recherches experimentales . Substances calorigenes et frigori- 

 genes d'origine microbienne; Pyretogenine et Prigorlgenine 

 (Experimental researches. Calorigenic and frigorific substances 

 of microbial origin; Pyretogenine and Prigorlgenine.) 



Gaz. d'Hopit. (Paris) 62:171, I889 



Fever and chills were caused by two separate principles residing 

 in bacteria; these were released by lytic action of enzymes and 

 diastases within the body. Roussy isolated these substances 

 from gram-negative organisms. 



