- 1 8 9 2 - 



was succeeded by marked leukocytosis. The latter was mainly 

 an increase in eosinophils, and the neutrophils were only 

 slightly increased. The increase in leukocytes often lasted 

 over 72 hours. 



-18 9 3- 



18. CENTANNI, E. 



Ueber infektious Pieber. Das Fiebergift der Bactereri (On in- 

 fectious fever. Fever toxins of bacteria) 



Deutsch. med, Wchnschr. 20:148-150; I76-178, 1893 Reforma Med, 256, 

 1893 



A number of pathogens were investigated for the presence of the 

 fever toxin: Diplococcus pneumoniae , B. typhi , B, coli , B. 

 aerogenes and pyocyaneus, the pyrogenic Staphylococci and that 

 of erysipelas, the bacilli of anthrax and tuberculosis, the 

 vibrio ( Metschnikof f , Finkler , and Deneke ) and the organisms of 

 tetanus. Influenza and diphtheria. Activity for fever pro- 

 duction appeared to be present in all these toxins and in ex- 

 tracts from the bacterial cells. Centanni found pyrogenic 

 ability of bacterial toxins was not proportional to toxicity; all 

 appeared to contain the same volume of Pyrotoxina bacterlca, a 

 water-soluble concentrate, non -albuminoid in character. 



19. COLEY, W. B. 



The treatment of malignant tumors by repeated inoculations of 

 e]:'ysipelas: With a report of ten original cases 



Am. J. Med. Sci. 105:487-489, I893 



Pure culture material of S. erysipelatis was injected in ten cases 

 of inoperable or recurrent carcinoma or sarcoma. Even without 

 production of frank erysipelas, response was favorable, parti- 

 cularly in the sarcomas. The curative action is believed to be 

 a systemic rather than a localized one, 



20. RUMPF, T. 



Die Behandlung des Typhus abdominalis mit abgetodtaten Culturen 

 des Bacillus pyocyaneus (Treatment of typhus abdominalis with 

 killed cultures of Bacillus pyocyaneus ) 



