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 Deutsch. med. Wchnschr, 19s 987, 1893 



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21. CENTANNI, E. 



Ueber Infektlous Fieber (On infectious fever) 

 Chera. Zentr. (4th Series) 6:597, 189^ 



Pyrotoxina bacterica , the fever-producing substance from bact- 

 erial cells, was extracted from the organisms following a period 

 of heating (3 hours at 60° C.) and subsequently a more intense 

 treatment at the boiling point. Filtration through a porous 

 clay filter followed; the concentrate was precipitated with 

 absolute alcohol, and the albuminous fraction removed. Repre- 

 cipitation and dialysis precedes drying in vacuo . 



Administered in superficial vessels under the; skin, a chemo- 

 tactic reaction of the local variety is produced. No suppura- 

 tion appears, but there is a powerful leukocyte attraction. 

 Larger doses bring forth a flattened , edematous swelling and adja- 

 cent blood vessels become hemorrhagic . The chromatin portion 

 of the bacterial cell may be the site of origin of the fever 

 toxin. 



22. TEISSIER, J. 



Des Pyrexies apyretiques ■ (Atypical fevers) 

 Semo med, (Paris) 14:197-199, l894 



Teissier noted the prevalence of febrile conditions without 

 other symptoms of specific disease. 30 years later, he applied 

 the knowledge gained through his experience (with Rivallier and ^ 

 Reilley) to the treatment of disease making use of the 'propidon 

 of Delbet, a preparation secured by the digestion of Ps_. aeru - 

 ginosa , streptococci and staphylococci . 



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23. COLEY, W. B. 



