- 1 8 9 6 - 



for a period over four years, presented all varieties of car- 

 cinoma or sarcoma. Sarcoma was present In 93> carclncma and 

 epithelioma in 62 patients, "Of the cases of sarcoma nearly 

 one-half showed more or less improvement; the variety that 

 showed the greatest improvement was the spindle-celled , that 

 which showed the least, the melanotic »" 



- 1 8 9 8 - ■ 



28, BATTLE, Wo He 



A case of sarcoma treated with Coley's Fluid 



Brit, Med„ J, 2:155^* I898 



The complete disappearance of a large tumor of the clavicle, with 

 axillary metastases, followed treatment with Coley's fluid, 



29= COLEY, W, Bo 



The treatment of inoperable sarcoma vjlth the mixed toxins of 

 erysipelas and Bacillus prodigiosus and final results in l4o 

 cases 



J.A.M.A. 31^389; 456, 1898 



The differences between tumor ipesponse to mixed bacterial toxins 

 are pointed out. Results thus far would indicate that the most 

 successful therapeutic results are secured in treatment of 

 spindle-celled sarcoma. In which favorable response has been 

 secured in 50^ or more of the cases. Far more resistant are 

 round -celled sarcomata. No Improvement in melanotic sarcoma 

 has become permanent. The action of the mixed toxins appears 

 to be one of coagulation-necrosis with fatty degeneration, 

 unlike inflammation or local escharotic effects. That the action 

 is specific is shown by the regression which occurs when in- 

 jections are made subcutaneously and in sites removed from the 

 tumor. 



The dangers attendent on this type of therapy are those of 

 shock, with circulatory collapse, and pyemia of septic origin. 

 The use of the toxins after surgical removal of the tumor is 

 advocated. Mild doses are advocated for this purpose. 



