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38. BENDIX, B., and BERGMANN, J. 



Uber das sogennante Kochsalzf ieber (On the so-called Salt 

 Fever') 



Monatschr. f. Kinderhellk. 11:337-88, 1911 



After injections of physiologic saline solution^ unexpected 

 temperature Increases were noted. Careful preparation of the 

 solution and care in injection appeared to prevent the reaction 

 which was considered to be the result of bacterial contamina- 

 tion. 



39. HORT, E. C. and PENPOLD, W. J. 



The dangers of saline injections 



Brit. M. J. 2:1589, 1911 



In a study of the undesirable effects which frequently follow 

 injection of saline solution in both humans and animals, the 

 authors listed: the production of fever, rigors, subnormal 

 temperature, diarrhea, intestinal hemorrhage, Cheyne-Stokes 

 breathing, and, with hypertonic solutions or rapid injection, 

 convulsions and sudden death. Pulmonary edema may follow the 

 injection of large amounts of solution. Vaculation of hepatic 

 cells and changes in heart muscle and renal tissue have been 

 noted on histologic examination. Bacterial products in ^^?ater^ 

 and not the saline^ are responsible for these changes. After 

 filtration and heating of water, 19^ of the animals used in 

 this study showed slight febrile reactions; only a few organisms 

 were found on culture, and the protein content was very small. 

 When freshly distilled water was used for solutions, few 

 reactions occurred, but when water was used after standing in 

 sterile vessels, fever was produced in direct proportion to 

 the amount injected. A solution containing 73,000 organisms 

 per cc , was used 10 days after distillation; it produced a 

 far less intense elevation of temperature than a sample two 

 months old which contained but 40 organisms. When the con- 

 taminated solution was centrifuged, the pyrogenic substance 

 v^as found to be concentrated just below the surface of the 

 supernatant fluid. This pyrogen was heat-stable and passed 

 readily through a Berkefeld filter. 



40. KILIANI, M. 



Pharmakologische Wertbestimmung der technischen Piebermittel 

 (Pharmacologic evaluation of technical fever materials) 



Arch, inter, d. pharmacodyn. et d. therap, 20:333-352, 1911 



