15 



-19 11- 



The reduction of the population of malarial parasites is 

 accompanied by a change from severe leukopenia to a marked in- 

 crease in white cells. Five to ten million dead parasites 

 mixed with corpuscles will stimulate leukocytosis for one hour; 

 this is a good diagnostic sign for malaria. 



In Hodgkin's disease a daily variation in leukocytes from 6,000 

 to 754-000 per cm,, may be noted. The mononuclear cells account 

 for 50 to 80 per cent of the increase. A similar change is seen 

 in cancer of the stomach, but fever is absent. The similarity 

 between the leukocyte picture in malaria and that seen in 

 malignancies leads one toward acceptance of the virus theory 

 of etiology for the latter. 



45. WECHSELMANN, W. 



Neuere ETfahrungen uber Intravenbse Salvarsaninjektionen ohne 

 Reaktions Erscheinungen (More recent experiences with intraven- 

 ous salvarsan injections without appearance of reactions) 



Munch, med, Wchnschr, 58:1510, I9II 



Febrile reactions after salvarsan injection were frequently 

 reported in the literature during the first five years after 

 use of the Ehrlich synthetic began, German physicians sought 

 to place blame upon the solvent (Wasserfehler) while French 

 writers considered the inherent toxicity of arsephenamin re- 

 sponsible, Wechselmann found that temperature elevations per- 

 sisted in some instances after special treatment and prompt 

 use of the distilled water solvent. The toxic principle 

 therein resisted both autoclaving and filtration. 



- 1 9 1 2 - 



46, GREENWOOD, H, H. 



Note on a case of melanotic sarcoma treated by Coley's Fluids 



Lancet 25.881, I912 



Coley reported that the mixed toxins of Str. erysipelatis and 

 B, prodigiosus were of very limited benefit in melanotic sarcoma, 

 A report is presented of the recurrence, in a rapidly spreading 

 form, of melanotic sarcoma previously removed by surgical means. 

 As a last resort, the mixed toxins were administered. The 

 patient had a complete regression and regrowth had not occurred 

 in one and one-haif years. 



