21 



- 1 9 1 6 - 



63. GAY, F„ P,, and CHICKERING, H. T. 



Studies In Typhoid Immunization, VI, Treatment of typhoid 

 fever by intravenous Injections of polyvalent sensitized typhoid 

 vaccine sediment 



Arch, Int, Med „ 17:303-328, I916 



64. HEKTOEN, L. 



Vaccine treatment 



J.A.MoA. 66:1591-159i^, 1916 



In subacute and chronic localized infections, specific vaccines 

 have, when properly used, valuable stimulatory properties on 

 leukocyte activity and on specific antibody mechanisms. In 

 typhoid fever and, perhaps, in other Infections, intravenous 

 Injection of specific vaccines and other substances may Induce 

 crisis by activity either superimposed upon or varying from 

 the stimulation of antibody production. This the author sees 

 as "a new and Interesting development in the study and treatment 

 of infectious diseases," 



65, JONA, J, L, 



A contribution to the experimental study of fever 



J. Hyg, 15: 169-194, 1916 



A non-protein thermogenic factor was Isolated from B. coll 

 communis and E, typhosa. It was colloidal in form, thermo- 

 stable in dry heat at 110^ C, and resistant to boiling. Or- 

 ganic solvents were ineffective. In combination with calcium 

 it formed inert salts. In minute quantities (4 gammas) it 

 produced fever in the rabbit, 



660 MILLER, J. L, and LUSK, P. B, 



The treatment of arthritis by the intravenous injection of 

 foreign protein 



J.AoM.A, 66:1756, 1916, See also: J,A.M,A, 67:2010, I916 



Typhoid vaccine was given intravenously for the relief of 

 arthritis. Relief of pain followed. The treatment was 



