22 



- 1 9 1 6 - 



considered primarily one of 'shock'. Unfavorable reactions 

 occurred. In addition to the expected rise in temperature, 

 marked chills, severe malaise and headache were encountered. 



67. VAUGHAN, V. e*, JR. 



Poisonous Proteins, Protein Fever 



Herter Lecture. J. Lab. Clin. Med. 2:15, I916 



The author quotes extensively from other authors in the 

 support of his theory that fever is the result of internal de- 

 struction of proteins. Bacterial infection in its active 

 phase is caused by liberation of 'protein poison' from bacterial 

 cells. This 'protein poison' is the keystone of all protein 

 molecules and is toxic only when set free. Once released, it 

 possesses the power to destroy the structure of other prorelns 

 through the removal of one chemical group. 



-1917- 



68. DAVIS, B. P. and PETERSEN, W. P. 



A comparative study of lymph and serum ferments during protein 

 shock reactions 



J. Exper. Medo 26:699-706, I917 



A preparation obtained from cultures of B. coll produced shock, 

 increased the flow of lymph and antif erments, and raised pro- 

 tease titers. The concentration of lymph fluid is not parallelled 

 by serum changes. The peptidase titer is not increased in 

 proportion tea protease. Diastase was found to be unchanged. 

 A rise in lipase was noted, 



69. DOCHEZ, A. R. and AVERY, 0. T. 



The elaboration of specific soluble substance by pneumococcus 

 during growth 



J. Exper, Med, 26:447, 1917 



During the growth of young cultures of pneumococci and parti- 

 cularly during the period of maximal multiplication, a specific 

 substance is elaborated by the bacteria and is found in cell- 

 free filtrates. Disintegration of the cell is not required 

 for its liberation. It is stable to high temperatures and 



