24 



- 1 9 1 7 - 



cyanosis. The second phase brought a rapid temperature rise 

 which reached its peak in 3 to 5 hours. Defervescence extended 

 over some 18 hours. Leukopenia was found during the first 

 phase. The rise in polymorphonuclear cells followed temperature 

 increases. Blood pressure was decreased during the entire 

 period (10 to 15 mrao Hgo) and returned to pre-injection levels 

 within a few days. Coagulation time was unchanged. Three 

 patients were improved under therapy, and typhoid was ap- 

 parently aborted in a second case. There was no improvement 

 in two cases and one fatality followed. 



73. KRAUS, R,, PENNA, J. and BONORINO, C, J, 



Ueber Heterobakterientherapie (On heterologous bacteria therapy) 



Wiener klin, Wchnschr. 30:869-870, I917 



The therapeutic effects derived from a preparation made from 

 the colon bacillus resembled those secured through the use 

 of typhoid vaccine. The same nonspecific and generalized 

 reaction follows foreign protein therapy. A single substance 

 present in all three materials must be the active agent. 



74. MEYER, J. and CARLSON, A. J. 



Hunger and appetite in fever 



Am. J. Physiol. 44:222-226, 1917 



In an attempt to determine the effects of fever on hunger con- 

 tractions and the mechanism through which such effects are 

 mediated, hunger contractiions in the stomach of gastric fistula 

 dogs were observed during a 24 hour period of starvation. 

 After observation of the normal fasting functions of the 

 stomach, the effects of intravenous or subcutaneous injection 

 of the following pyrogenic materials were measured: sodium 

 nucleate, killed B, prodigiosus cultures, peptone, typhoid 

 vaccine and caffeine citrate. ^The changes in hunger contrac- 

 tions produced by external heat were also recorded. Sodium 

 nucleate, B, paratyphoid , tetanus and diphtheria were Incubated 

 with pylorTc strips. Sectioning of splanchnic and vagus nerves 

 and its effect on pyrogenic changes revealed the fact that 

 lower vagus tone appeared to inhibit hunger contraction, but 

 no association with the plexuses in the splanchnic area coilJld 

 be traced. Starvation of neonatal puppies did not induce fever. 

 In, vitro bacterial toxins did not alter activity of stomach 

 muscle. Temperatures of 103° P. prevented hunger contractions. 



