25 



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75. SCULLY, F. J. 



The reaction after intravenous injection of foreign protein 



J.A.M.Ao 69:20-23, 1917 



Patients with articular arthritis experienced pronounced reac- 

 tions after intravenous typhoid vaccine Injections. A chill, 

 accompanied by marked leukopenia, was first noted; rising 

 tem-perature followed with maximal levels appearing within 

 3 or 4 hours. Leukocytosis, with the absolute increase 

 largely a matter of neutrophil multiplication, marked the max- 

 imal point. The blood pressure mounted during the chill and 

 declined thereafter. Hypotension persisted for 3 to 4 hours, 

 and the return to normal levels was a gradual one. Relief from 

 joint pain was reported by 40^ of the patients after a single 

 Injection; over one-half were benefited by 2 or more Injections. 



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76. AULD, A. G. 



Pyrogenic therapy. With remarks on colloidal metals 



Brit. Mo J. ia95, 1918 



Various colloidal metals may exert a pyrogenic effect when 

 parenterally Introduced, In the course of his Investigations 

 the author found a marked reaction could be stimulated by the 

 use of a colloidal platinum preparation over one year old. On 

 injection of this material a sharp rigor followed, then pyrexia, 

 headache, and perspiration. The blood pressure reached high 

 levels during the chill period and fell in the febrile interval; 

 the leukocytes began to rise as the fever increased , 



A suspension of colloidal silver was markedly effective In 

 producing the reaction. The investigator deduced from the 

 identical effects elicited by these metals that the m^tal 

 Itself was not the pyrogenic agent, "If the pyrogen. . .was 

 not colloidal platinum, it matters little therapeutically, as 

 all pyrogenic agents in appropriate doses produce the same 

 effects.,,, Under present conditions typhoid vaccine is prob- 

 ably the best pyrogen to use..." 



