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77. HASHIMOTO, M. 



Pleberstudlen uber die spezifische ueberernpf Indlichkeit des 

 Warmzentrums an sensiblslerten Tleren (Fever studies on the 

 excessive sensitivity of heat centers in sensitized animals) 



Arch. Exper, Pathol. (Leipzig) 78:370-373, 1918 



A primary injection of heterologous protein sensitizes 

 certain cells of the temperature-regulating centers » When 

 the specific antigen is again introduced, an immunologic, 

 reaction occurs and fever appears, 



78, HASHIMOTO, M, 



Pleberstudlen, II. Uber die Einfluss unmittelbarer Erwarmung 

 und AbkQhlung des Warmzentrums auf die Temperaturwirkungen 

 von verschiedenen pyrogenen und antipyretlschen Substanzen 

 (Pever studies. II. The influence of direct heating and 

 cooling of the heat centers upon the temperature-activity of 

 various pyrogenic and antipyretic substances) 



Arch. Exper. Pathol. (Leipzig) 78:39^-395, 1918 



Pyrexia induced by typhoid vaccine and by anaphylactic shock 

 can be modified by direct heat or cold applied to the heat 

 regulatory centers. The action of some antipyretics is altered 

 by these measures. 



79. MEYER, J., COHEN, S, J.^and CARLSON, A. J. 

 Gastric secretion during fever 



Arch. Int. Med. 21:35^-365, 1918 



The underlying mechanslm affecting gastric secretion during 

 fever was studied further through observations of Pavlov 

 pouch dogs in which fever was Induced by intravenous injections 

 of sodium nucleate, inactivated cultures of B. prodlgiosus or 

 external heat. Determinations were made of both free and total 

 HCl, pepsin, chlorides and total secretion volume. 



External heat (to increase body temperature 2 to 4° P.) or 

 pyrogenic substances decreased total and free acid in gastric 

 secretion, as well as the total volume. A relative increase 

 in pepsin and slight chloride reduction were recorded. During 

 fever, gastrin was ineffective. It was believed that toxins 

 elaborated during fever directly depress the secreting mechanism 

 in the stomach. In particular, the secreting powers of the cells 

 are reduced to a point where nerve impulses can no longer stim- 

 ulate activity. 



