27 



-19 18- 



80o WELLS, C. W. 



Leukopenia and leukocytosis in splenectomized rabbits 



J. Infect. Dis. 22:502-506, I91S 



The spleen may exert an influence over the total number of 

 leukocytes during the period of Increase which follows the 

 administration of killed bacteria. In initial leukopenia, 

 the fate of the -leukocytes in the blood from bone marrow and 

 liver parenchyma was studied. Normal levels were maintained 

 in one instance. The mechanism involved was not determined. 



- 1 9 1 9 - 



81, BALCAR, J. 0., SANSUM, W. D. and WOODYATT, R, T. 



Fever and the water reserve of the body 



Arch. Int. Med. 24:116-128, I919 



The appearance of so-called 'thirst' or 'inanition' fevers 

 (which include the dietary fevers of infants and 'sugar' and 

 'salt' fever in children and adults) is considered a result 

 of (a) binding of water by electrolytes or organic molecules 

 (b) inadequate amounts of water available for evaporation (c) 

 increased peripheral temperatures. In fever the normal body 

 reserves of water are bound by colloids to an abnormal degree. 

 The marked diuresis and perspiration v^hlch follow the dissolu- 

 tion of fever by crisis are evidences of water liberation. 

 Intake of additional fluid would, rationally, reduce fever. 

 Glucose in solution may, when given intravenously at a rapid 

 rate, encourage water loss through glycosuria diuresis and 

 produce typical 'thirst' fever. Loss of water, which has 

 a high specific heat, may depress the process of evaporation. 

 Hypertonic glucose in a single large Injection did not result 

 in pyrexia except where the water reserve was previously 

 depleted , 



82. COWIE, D. M, and CALHOUN, H, 



Nonspecific therapy in arthritis and infections. A study of 

 the changes in the blood consequent to the intravenous injection 

 of typhoid protein. A consideration of the analogy between the 

 typhoid paroxysm and the malarial paroxysm. 



