28 



-19 19- 



Arch. Int. Med, 23:69-131, 1919 



Ten case reports of patients suffering from arthritic disease 

 or infections are presented. Intravenous typhoid vaccine was 

 injected after prior determinations of both total and differ- 

 ential leukocyte counts. The usual picture of leukopenia 

 followed injections. Leukocytosis appeared during the pyrexial 

 response. Atypical lymphocytes, nucleated red cells and myelo- 

 cytes were found in increasing numbers as the white count in- 

 creased. There was no eosinophilia . Patients who had definite 

 myelocytic response exhibited the best clinical improvement. 

 During fever, swelling and heat increased in Joints, 



Malarial therapy brings responses similar to those observed 

 after the administration of typhoid vaccine; the common etiolo- 

 gical factor in the reaction is believed to be a protein. The 

 reaction is not an anaphylactic one since eosinophilia is ab- 

 sent. In the leukopenic phase the neutrophils leave the blood 

 stream and enter the tissues; the leukocytic phase is character- 

 ized by overproduction of cells by 'their respective mesenchymal 

 fundaments, ' 



83. GOW, A, E. 



A note on certain phenomena associated with the protein shock 

 reaction and intravenous vaccine therapy 



Quart, J, Med, 13:82, 1919 



After a brief review of the literature describing the use of 

 bacterial proteins, the writer presents 8 case histories illus- 

 trating the application of this type of therapy to varied disease 

 entities, Coliforra bacteria, streptococci, and organisms asso- 

 ciated with respiratory disease were used in the preparation of 

 vaccines. Symptomatic and clinical remissions were obtained in 

 5 patients. Only with the colon type vaccine was marked leuko- 

 cytosis noted. 



84. MtJLLER, E. P. 



Die Bedeutung des Kasiens in der Milchtherapie (Significance of 

 casein in milk therapy) 



Munch med. Wchnschr. 66:1233, 1919 



The protein in milk does not produce fever after intravenous 

 injection. Milk, from which casein had been removed, still 

 produced fever when injected. An endotoxin of bacterial origin 

 is responsible for such pyrogenic activity. 



