30 



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89 » WALKER^ I. C. 



The treatment of bronchial asthma with vaccines 



Archo Int. Med„ 23? 220-234, 1919 



A group of 178 patients received bacterial vaccines In the 

 treatment of bronchial asthma. Of these, 28 were found to be 

 sensitive to bacterial proteins and were treated with vaccines 

 prepared from organisms to which they were sensitized « The 

 remainder were treated with vaccines from organisms found in 

 sputum or nasal secretions. 



Sensitized patients treated with vaccines received much benefit 

 from this type of therapy (75 per cent relieved, 21 per cent 

 improved). Vaccines prepared from organisms grown on plain 

 agar were somewhat less effective (46 per cent of the patients 

 so treated were relieved; I6 per cent only Improved), When 

 dextrose bouillon was used for culture of streptococci, 37.5 

 per cent of the patients treated with a vaccine prepared from the 

 cultures were freed from symptoms, and 25 per cent showed some 

 improvement. Combinations of the two types of vaccines were 

 least effective. 



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90, BARBOUR, H. G. and HOWARD, H, G, 



Coll fever and blood volume (in dogs) 



Proco Soco Exp, Biol, Med, 17s 148-150, 1920 



The antipyretic effect of Intravenous dextrose is not noted in 

 the healthy dog, but in febrile conditions produced by Injections 

 of E. coll organisms. It exerts a distinct fever-reducing effect. 

 The mode of action of dextrose is not clear; It may give osmotic 

 support through increasing the fluidity of the blood at a rapid 

 rate. Such an alteration would aid in the elimination of heat. 



When subcutaneous injections of killed colon becillus prepara- 

 tions were given, sterile abscesses developed in the dog. The 

 blood solids Increased at a rate parallel to Increases in body 

 temperature; the hemoglobin was concentrated. Loss of blood 

 fluidity In fever reduces blood volume and lowers the rate of 

 heat elimination. 



