35 

 - 1 9 2 2 - 



104. BARR, D, P,, CECIL, R. L. and DUBOIS, E, F. 



Clinical calorimetry, XXXIII. Temperature regulation after the 

 Intravenous injection of proteose and typhoid vaccine 



Arch. Int. Med. 29:6o8-6lO, 1922 



Heat production In human beings Increased from 75 to 200 per 

 cent during the chill produced by proteose or typhoid vaccine. 

 Heat elimination did not increase. Equalization with the en- 

 vironmental heat followed, and elimination was from 20 to 40 

 per cent above the basal levels. After heat production ceases, 

 elimination continues, producing lower values. That a rapid 

 consumption of glycogen occurs during febrile phases may be 

 ascertained from records of respiratory quotients made during the 

 chill phase. Fever is not caused by failure in the elimination 

 of water. The velocity of chemical reactions follows van't 

 Hoff 's law (30 to 6o per cent Increase for each 3 C, rise be- 

 tween 37 and 40° C . ) . 



1C5. PENPOLD, W. J. and ROBERTSON, D. G. 



Haemolytic and water fevers 



Med. J. Australia 1:129, 1922 



The role of bacteria and bacterial products in the production of 

 'water' fever is discussed. 



-19 2 3 



FTJRTH, 0. and LANDSTEINER, K, 



On precipitable substances derived from Bacillus typhosus and 

 Bacillus paratyphosus B, 



J. Exper. Med. 47:171-176, 1923 



Extraction of a culture of E, typhosa through the use of boiling 

 75 per cent EtOH yielded an antigenic precipitate, insoluble in 

 water, but soluble in weak alkali. It contained traces of phos- 

 phorus and 15.7 per cent nitrogen (ash-free preparation). After 

 hydrolysis for five hours, there is little reduction of Pehllng's 

 solution. Tryptic digestion alters antigenic activity. A second 

 fraction was obtained by extracting cells with saline and preci- 

 pitating with 95^ alcohol. The fraction had a high nitrogen 

 content. Again tryptic digestion destroyed antigenicity. 



