37 



-19 2 5- 



HEIDELBERGER, M,, GOEBEL, W. F, and AVERY, 0. T, 



The soluble specific substance of a strain of Friedlander ' s 

 Bacillus 



Jo Exper, Med, ^2:701-707, 1925 



Isolation and chemical analysis of a nitrogen-free specific 

 polysaccharide from the E strain of Friedlander ' s bacillus are 

 described, > 



LING;, Co Yo 



The mechanism of reaction of nonspecific protein agents in the 

 treatment of disease. I.. The influence of various agents on 

 temperature and leukocyte counts in normal persons and In rabbits, 

 II. The influence of various agents on the mobilization of 

 blood antibodies. III, The influence of various agents on the 

 mobilization of blood enzymes in normal persons and in rabbits. 



Arch. Int. Med. 35:598-608; 790-795, 1925 



Therapy through induced fever is complicated by the fact that 

 leukocytes do not play the principal role in body defenses, in 

 spite of their phagocytic activity. These cells release endo- 

 lysins, which, like bacteriolysins, are bactericidal, and 

 elaborate protease and peptidase likewise. The rise in the leuk- 

 ocyte count is caused by an accelerated production 6f myeloid 

 elements; it varies with the agent employed and the degree of 

 infection present. 



Seven foreign proteins and distilled water alone were administered 

 to rabbits and to human beings. Typhoid vaccine (0,2 cc , per kg, of 

 body weight), containing 100 million organisms per cc, anu market 

 milk were responsible for the production of more intense pyrexia 

 than other proteins used. Bacterial products increased titer 

 against E, typhosa and Staphylococcus aureus in unsensltized indi- 

 viduals. Complement in serum was depressed, but natural anti- 

 sheep hemolysin was not affected. The slight trauma and bleeding 

 seen in injection has, in itself, a slight nonspecific stimu- 

 lating effect. The production of large amounts of proteolytic 

 enzyme after foreign protein injection may be either an elabor- 

 ation by tissue cells in defense or acceleration of the lymph 

 flow from the intestinal tract, or both. Detoxification through 

 the digestion and elimination of bacterial, toxins may occur. Pro- 

 teolytic activity was much Increased when typhoid vaccine was 

 injected; it decreased steadily after the initial dose. Peptone 

 decreases proteolysis initially, but a rise takes place soon after. 

 Lipolytic activity in serum was temporarily increased. 



