46 



19 2 7 



138. MUELLER^ E. P. 



Nonspecific protein therapy: Its action and its application 



Wisconsin M. J, 26:287-288, 1927 



In nonspecific protein therapy the V3getative nervous system 

 alters and produces early changes tnrough the splanchnic 

 areao Major internal organs are mobilized into rhythmic action, 

 followed by reflex action at the periphery which decreases 

 capillary capacity. 



139 o SEIBERT^ P. Bo 



II '* 



Welche substanzen erzeugen Pieber nach intravenoser Injektlon 



(What substance produces fever after intra^/enous injection?) 



Arch. Exp, Path. Pharmakol. 121:247-249, 1927 



The author opposes the theory of Donath and his school, holding 

 that fever after intravenous injection of distilled water is 

 caused, not by nucleic acid, but by a metabolic product of 

 the bacterial contaminants. 



140. STOKES, J. H, 



Modern Clinical Syphllology 



Philadelphia, W. B. Saunders Co. 1st Edition, 1927, pp. 177; 



346 



The "water error" (Wasserfehler) is commonly found on large 

 dermatologic services where large amounts of distilled water 

 are prepared in advance. Showers of reactions, with chills and 

 fevers were noted Mondays on the author's clinic. The 'tubing 

 reaction', first described by Stokes and Busman, is character- 

 ized by the appearance, within 30 minutes after an injection, 

 of malaise, pain in the lumbar region, nausea and diarrhea with 

 tenesmus. The chill may be the first symptom. With repetition 

 of the rigor, sharp rises in temperature may be seen. There is 

 often prostration and emotional disturbance. The fever may 

 persist beyond the usual 8 hours. Profuse outbreaks of herpes 

 have followed the reaction. Leukocytosis (with 96 per cent 

 polymorphonuclear cells) is present. 



The use of nuclein in neurosyphilis, advocated by Pischer and 

 by Meyer, is discussed at length. Pischer observed remissions 



