47 



- 1 9 2 7 - 



In 58 per cent of the patients treated. He found sodium 

 nuclelnate to be a useful substitute. The Initial dosage used 

 was 2,5 to 3 cc o of a 10 per cent solution j Interrupted treat- 

 ment was the most successful. The marked leukocytosis, not 

 fever produced., received credit for therapeutic benefits, 

 Meyer J, in comparing nucleln with tuberculin and arsephenamlne 

 alone, reported successes in 42 to 50 per cent of cases treated 

 with the former. Tuberculin produced remissions in but 25 per 

 cent of the cases treated; arsephenamlne, in 7.0 to 7.5 per cent, 



141. TEISSIR, P., REILLY, J, and RIVALIER, E. 



Recherches experlmentales sur 1' infection chancrelleuse. I. 

 Preparation d ' une antigene Streptobaclllaire soluble (Ses Effets 

 sur 1' animal et I'homme) (Experimental ini/estlgatlons on 

 chancroid infection, I, The preparation of a soluble antigen 

 Streptobacillln . Effects in animal and man.) 



J. Physiol, et Path. 25:268-282, 1927 



"Streptobacillln " a homologous vaccine-type extract, was prepared 

 from Ducrey's bacillus. A mixture of nucleoproteln-globulln 

 complexes, it is non-toxic to mice, guinea pig or healthy humans 

 in the ordinary dosages. On intravenous injection certain 

 reactions associated with protein 'shock' were noted. The sub- 

 stance may be used by subcutaneous or intradermal Injection, 

 as well. The preparation appears to have sensitizing activity; 

 marked reactions occurred when injections were given to persons 

 already Infected with the bacillus. There was no complement 

 fixation or inactivating ability in serum after the use of the 

 extract, the precipitin reaction was feeble, and no bactericidal 

 activity could be demonstrated. 



142, TEISSIR, P., REILLY, J„ and RIVALIER, E, 



Recherches exper^mentales sur 1' infection chancrelleuse, II. 

 Les prlncipes genf^raux d ' une vacclnotheraple speclfique (Experi- 

 mental investigations on chancroid infection, II. General 

 principles of specific vaccine therapjr) 



J. Physiol, et Path, 25:319-338, I927 



The respective values of specific vaccine therapy and nonspecific 

 protein therapy for the treatment of chancroid were compared, A 

 homologous vaccine "Streptobacillln" was administered to persons 

 infected with Ducrey' s bacillus and the therapeutic results ob- 

 tained appeared to parallel the degree of sensitization, most 

 marked in conditions of long standing. The results would suggest 

 a provocation of inflammatory processes, favoring leukocytosis 

 and phagocytosis. 



