51 

 - 1 9 2 8 - 



between the degree of erythema after preparatory Injection and 

 the intensity of the hemorrhagic reaction produced by Intra- 

 venous filtrate. Skin preparation with nonspecific irritants 

 did not render tissues responsive to subsequent injections of 

 filtrate. Neither did the Injection of the bacterial filtrate 

 into the skin provoke the hemorrhagic -necrosis phenomenon, 

 which is not related closely to bacterial hypersensitivity„ 

 The filtrates themselves resisted inactlvation by heat at a 

 range of pH between 4oO and 9oOo 



153. TOMCSIK, J. and KUROTCHKIN, T„ Jo 



On the role of carbohydrate haptens in bacterial anaphylaxis 



J. Exper, Med, 47:379-338, 1928 



Carbohydrate haptens obtained from B, lactis aerogenes , the 

 pneumobaclllus and from a yeast were found capable of producing 

 anaphylactic shock in vivo and in vitro In guinea pigs passively 

 sensitized with immune rabbit sera. Toxic and minimal shock - 

 producing doses were found to have a wide margin, corresponding 

 to those noted in protein anaphylaxis. Active sensitization 

 could not be produced with these substances. 



-19 2 9- 



154. BREUER, S. 



Insullnartlge Substanzen aus Bacterium coll und Rauschbrand- 

 bakterien (Insulin-like substance from^„ coll and Blackleg 

 bacteria) 



Munch, med, Wchnschr, 76:741-742, 1929 



Filtrates from two cultures of B, coll were Injected into the 

 rabbit, A severe hypoglycemia followed, similar to but less 

 marked than that produced by Insulin; it was relieved by the 

 administration of sugar. The filtrates from cultures of Clos - 

 tridia chauvoei vjere four times as active as those prepared from 

 B, coll but were orally inactive. When concentrated through use 

 of acid alcohol, the potent principle was thermostable. 



