52 



-19 2 9- 



155. FREMONT -SMITH, Lo, MORRISON, R. L., MAKEPEACE, A. W. 

 Capillary flow in man in typhoid vaccine fever 



J. Clin. Invest. 7:^89, 1929 



Changes in the capillary blood flow appear in three stages. At 

 the onset of fever complete stasis begins, with cyanosis 

 appearing at the height of the reaction. As fever mounts, the 

 blood flow is increased. The typical flush is seen near the 

 peak of febrescence; it continues throughout the succeeding fall 

 in temperature and, occasionally, for some hours thereafter. 



Stasis is initiated by a rapid constriction of the terminal 

 arterioles and is prevented by the local application of heat. 

 It also can be abolished once it has begun by the same means. 

 Constriction in renal blood vessels leads to water retention 

 and a subsequent dilution of blood, producing diuresis in the 

 later stages of fever. 



156. GROLLMAN, A. 



Variations in the cardiac output 6f man. Vo The cardiac output 

 of man during the malaise and pyrexia following the injection 

 of typhoid vaccine 



J. Clin. Invest. 8:25-32, 1929 



The cardiac output, pulse rates, blood pressure, temperature 

 and oxygen consumption of 8 individuals were studied after the 

 intramuscular injection of typhoid vaccine. Soon after injection 

 the cardiac output was increased to a significant degree, but 

 at the height of malaise and fever, the output was somewhat 

 reduced. Pulse rate and oxygen consumption parallelled the 

 degree of malaise and of fever. 



157. HOFP, P. 



Ueber den Einfluss von Baktierieneiweiss auf das Blut (Influence 

 of bacterial protein on the blood) 



Verho Deutsch, ges . inn. Med, ^Ist Kong. Inn. Med. 208-211, I929 



The influence of bacterial protein on cellular and chemical 

 elements, volume and rate of flow of the blood is discussed. 



