5S 



- 1 9 3 1 - 



Saline 'fever' may appear after a single dose of hypertonic so- 

 lution given orally or after repeated oral administration of 

 hypotonic or isotonic solutions. Amounts as small as 50 cc. per 

 kilogram of body weight may bring temperature increases. Ringer's 

 solution has similar hyperthermic effects. The pattern of reac- 

 tion is one of defense against disturbance of normal tissue con- 

 centrations of salts; the reaction diminishes the pressure grad- 

 ient with the production of fever. This last-named phenomenon 

 may be the culmination of tissue activity directed toward dehy- 

 dration. 



17^ c FINKELSTEIN^ H, 



Zur Kenntnis des alimentarien Piebers, VI o Hyperthermie Oder 

 Fieber? (information on alimentary fevers, VI, Hyperthermia or 

 fever?) 



Ztschr, Kinderh. 50:637-650, 1931 



When body cells are forced to 3;leld intracellular water, fever 

 appears. Protein and sodium chloride retain water and are addi- 

 tional factors in its diversion from its physical destination. 

 Desiccation of the liver during periods of high body temperature 

 produces profound alterations in body chemistry^ and colloid chem- 

 ical changes are seen in the body cells, "The, , .theory df pyro- 

 genous substances or protein split products as basic causes of 

 temperature elevations, , ohas inadequate background. Presence of 

 neither, , ecssential for fever production, " 



. o « o 



175. PINKELSTEIN, H. and WEIL, E. 



Zur Kenntnis des alimentarien Piebers V, Zur Pharmakologie des 

 Eiweiss-und Kochsalzfiebers (Information on alimentary fevers, V 

 Pharmacology of protein and saline fevers) 



Ztschr, Kinderh, 50:268-291, I931 



No distinction between hyperthermia and 'true' fever was found. 



176, GOLD IE, H, 



Les substances antlhemolyses (antihemo lytic substances) 



Compt, rend, Soc. blol, 109:7-9, 1932 



Thermostable and filtrable disaggregations of the products of cul- 

 ture filtrates of Streptococci , Staphylococci , E, typhosa and E„ 

 Goli exert a marked antihemolytic influence on ^he blood. While 

 the substances appear to be related to antibiotic and immunologic 

 factors in the bacteria, they are not present in very young or 

 •very old cultures. Purified products are crystalline NHg compounds. 



