61 



-19 3 1- 



decrease began 6 to 7 hours after adroinistratlono A sharp. 

 Initial leukopenia sometimes antedated leukocytosis; where 

 this occurred, stab cells made up approximately 50 per cent of 

 the total leukocyte count. Although It is an active hematopoietic 

 agent, pyrifer is not a cure in the final sense. In neurosyphi- 

 lis, it is a valuable adjunct in combined therapy. 



182. SABIN, A. R, and WALLACE, G. Bo 



On the nature of the chill-producing principle in anti- 

 pneumococcus serum 



J, Exper„ Med. 53:339-362, 1931 



A chill may occur 30 to 60 minutes following the injection 

 of anti-pneumococcus serum. It is accompanied and followed by 

 a rise in temperature which is prolonged for several hours. 

 Since the same reaction has been noted after intravenous injec- 

 tion of other solutions and in transfusion, a study of its 

 properties and origin was made. The influence of drugs upon 

 the chill-producing factor was ascertained. 



No relationships between the chill, anaphylaxis or the toxic 

 effects of drawn blood were noted. The principle appears to be 

 formed in blood after standing; it is not removed from solution 

 by anticoagulants, dialysis, filtration or moderate heat. It 

 was independent of the formed elements, the lipids or fibrinogen. 

 Fractionation methods, utilizing the changes in pH and NaCl con- 

 centration, removed acid and alkaline globulin fractions from 

 antibody solutions. The acid globulin apparently acts as an 

 adsorptive carrier for +-he chill-producing fraction, while the 

 alkaline globulin serves as a vehicle for the antibody substance. 



133. SHWARTZMAN, G. 



Phenomenon of local skin reactivity to bacterial filtrates in 

 the treatment of mouse sarcoma I80 



Proc. Soc. Exper, Biol. Med, 29:737, 1931 



Agar washings of Meningococcus 44D group I were filtrated and 

 injected intravenously into mice bearing sarcoma I80. Doses 

 ranging from C.25 to 0.5 cc, were given singly, as repeated 

 injections, and at varied time intervals during tumor growth. 

 The m.ajority of neoplasms responded with prompt hemorrhage 

 followed by complete regression or regression succeeded by 

 slow regrowth. The effect appears to be selective. The sub- 

 stance was highly toxic. 



