-19 3 1- 



l8i^* SOLARI, L. A. 



Temperature et reactions thermiques chez les chiens hypo- 

 physoprlves ou i tuber llse (Temperature and thermal reactions 

 In hypophysectomlzed or tuber-injured dogs) 



Compt. rend, Soc. biolo 108:125, 1931 



185, SPEIRER, C, 



Die unspezif Ische Behandlung des Gonorrhoe mlt Pyrifer (Non- 

 specific treatment of gonorrhea with pyrifer) 



Dermat, Wchnschr, 92:13-17, 1931 



Immunologic mobilization^, and not natural resistance^ are cardinal 

 features of all nonspecific 'fever' therapeutics. The authors 

 found a death point fdr gonococcl in vitro at 4^0 to 41° Coj others, 

 particularly Koch, have noted no absolute destruction through 

 heat in vivo „ A bacterial protein material from apathogenic colon 

 type bacilli (pyrifer) was used in treatment in all seven strengths 

 (50 to 500 million organisms) Pyrifer fever resembled that of 

 malaria. Most frequently encountered reactions were those of head- 

 ache, muscle pain and herpes lablalis. While pyrifer has a place 

 in the therapeutic armentarlum, it is not a panacea, 



186. WOLFF, L. K. and RAS, G. 



Uber unspezif Ische Theraple II. (On nonspecific therapy, II.) 



Ztschr, ges, exp, Med, 75^719-736, 1931 



A nonspecific bactericidal effect was found to be common to or- 

 ganic compounds (31), inorganic salts (12), biologic proteins 

 (12) and suspensions of dead bacteria (14), when these materials 

 were injected intravenously into the rabbit. When tolerance 

 to histamine developed, there was tolerance to all other materials 

 injected. Appearance of a tolerance to gram-negative bacilli 

 produced similar tolerance to all other gram-negative organisms, 

 but none to gram-positive bacterial preparations. When the 

 materials were Injected in a reverse order, the tolerance exhibited 

 likewise was in reverse. Subcutaneous Injection itself is 

 bactericidal. When leukocytes were destroyed by coagulation, the 

 blood and serum of the rabbit exhibited bactericidal properties. 



