64 



-19 3 2 



190- HENCH, P. S. 



Usual and unusual reactions to protein (fever) therapy- 

 Arch. Int. Med, 49:1^ 1932 



Physiologic changes during the "protein" reaction Include those 

 In basal metabolism and blood pressure, peripheral and splanchnic 

 vasomotor mechanisms and in size and permeability of the arter- 

 ioles and capillaries o Fluctuations In renal function are seen. 

 There may be pH, N, P, urea and uric acid, albumin and allantoin 

 concentration alterations and the amounts excreted may vary. 

 Immunological phenomena may be observed (antibody and complement 

 fixation) and the flow of bile, lymph, saliva, breast milk or 

 menses may be Increased. The activity of liver, gastrointestinal 

 tract and spleen may vary from the norm. Of physical changes 

 observed in blood, those of volume alteration, specific gravity, 

 freezing point and viscosity are most evident. There are certain 

 cellular blood characteristics which reflect the results of temp- 

 erature elevation; platelet fragility is increased and the con- 

 tent of fibrinogen may vary. Sedimentation rate may be affected. 

 Chemically, COg tension and combining power of plasma and total 

 NPN of whole blood and serum may reflect the general state during 

 fever. Sugar tolerance and the ratio of albumin to globulin 

 have shown variation in hyperpyrexia , 



191. MURRAY -LYON, R, M. 



Nonspecific protein therapy in rheumatism 



Edinburgh M. J. 39:619-627, 1932 



In chronic arthritis, typhoid vaccine or protein preparations 

 bring a temporary response only. In the subacute arthritic 

 conditions, typhoid vaccine may be beneficial. Its action on 

 collagenous tissue has not been explained, 



192 , NOUVELAS, P. A. 



Plrogenos; Mode de producto (Pyrogen production) 

 Siglo med. 89:77; lOSO; I63, 1932 



