66 



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197. DONAGGIO^ A» 



Curves showing the 'Inhibition phenomenon' in urine and spinal 

 fluid under various febrile conditions (Translated Title) 



Bollo soco ital. blol, sper, 8:l459-'1^62, 1933 



Hyperpyrexia Induced by injections of pyrogenic substances 

 (proteins and vaccines) does not cause immediate changes in the 

 urine and spinal fluid. Resistance is exhibited in a latent 

 period p extending 12 to 24 hours after the onset of ordinary 

 fever^ and to 36 hours after injection of pyrogens. No lag is 

 seen when fever Is Induced by physical means. Fever provoked 

 by the injection of malarial parasites is preceded by alterations 

 in urine and spinal fluid before the rise in temperature. The 

 inhibiting substance can be removed from fluids by dialysis or 

 by adsorption with bone charcoal or kaolin, followed by filtration o 



198, DURAN-RFfNALS, P, 



Reaction of transplantable and spontaneous tumors to blood -carried 

 bacterial toxins in animals unsusceptible to the Shwartzman 

 phenomenon 



Proc, Soc, Exper, Biol, Med, 31^341, 1933 



The tumor hemorrhage and necrosis which follows the Intravenous 

 injection of bacterial filtrates of B, coll was studied in rats 

 and mice, animals normally unsusceptible to the Shwartzman phen- 

 omenon. The majority of animals carried rapidly growing, malig- 

 nant tumors, a smaller proportion bore slower-growing spontaneous 

 or transplanted malignant growths, em^bryomas or granulomas, 



A strongly positive hemorrhagic reaction was seen in the group 

 bearing rapidly growing transplanted tumors; the larger the tumor 

 the greater, in general, was the reaction. Slower growing and 

 less malignant tumors were not affected. Animals bearing regressed 

 tumors were resistant to regrafted tumor tissue. Toxic effects 

 of the filtrate appeared to be related to the size and age of the 

 tumor. The investigators found only tumors showing malignancy 

 and rapid growth were capable of response to bacterial toxins, 



199- GIAJA, J. and DIMITRIJEVIG^ I. 



La thermoregularisation sur la flevre (Thermoregulation during 

 fever) 



Arch, int, pharmacodyn, 45:3^2, 1933 



