67 



- 1 9 3 3 - 



Fever caused by Induced Pyocyaneus Infection In rats did not 

 inhibit the temperature regulating apparatus of the brain 

 centers. The temperature remains high during wide variations 

 in environmental temperature. 



200^ GORDON, R. E. and STARK, C. N. 



The toxicity of young cells of S. paratyphi A and B when lysed 

 by bacteriophage. 



J. Infect. Dis. 62:45-47, 1933 



Young bacterial cells did not yield toxic fractions after auto- 

 lysis and f iltration^ but a slight toxicity was shown by prepara- 

 tions made from S. paratyphi A and B cells 6 or more days old. 

 The maximal toxicity was present between 8 and 14 days of age. 

 Aging again reduced the toxic factor. At room temperature for 2 

 months toxicity was gradually lessened. Filtration, additional 

 bacterial inoculations and low temperatures did not reduce 

 activity. 



201 . HSAIO -CH ' lEN , CHANG 



Gastric secretion in fever and infectious diseases 



J. Clin. Invest. 12:155-169, 1933 



Gastric acidity falls during febrile conditions and finally 

 reaches levels 66 per cent below the normal. Chloride ion 

 concentration falls with the volume of secretion. The decreases 

 are In direct proportion to the degree of fever. 



202. HEUBNER, W. and SILBER, W. 



Der Bestimmung der antlpyretlschen Stoffen (Testing of antipyretics) 



Arch, Exp, Path. Pharmakol, 169:530-536, 1933 



The most regular and enduring fever reproducible in rabbits is 

 seen after infusion of hay extracts. If subcutaneous injections 

 are used, no ill effects follow high temperature elevations. 

 The method may be employed for testing antipyretic drugs. 



