- 1 9 3 4 - 



216 « HOOPER, P. E., RENFREW, A. G. and JOHNSON, T. B. 



The chemical study of bacteria,, Studies on the complex car- 

 bohydrates isolated from the culture medium and the ultrafll- 

 trate after the growth of tubercle bacilli 



Am, Rev, Tuberc . 29s66-72, 193^ 



A fraction secured by the hydrolysis of a culture of tubercle 

 bacilli 6 weeks old contained d-galactose, d-mannose and 

 d-arabinose with a small amount of uronic acid. The nitrogen- 

 free ultraf iltrate contained a polysaccharide with identical 

 specific reactlvitys The polysaccharide did not contain phos- 

 phorus . 



217, HOWIE^ J, E, 



Observations on the use of pyrifer 



Jo Ment, Sci. 80s 521 -525, 193^ 



Pyrifer is a preparation produced from killed colon bacilli and 

 prepared in seven strengths, containing from 50 million to 

 500 million bacteria per cc. The initial dosage recommended 

 ranges from 25 to 50 million bacteria. The intravenous route is 

 preferred The febrile reaction begins one-half to 1 hour after 

 administration and reaches its height in 3 hours, falling by 

 l7/sis, A secondary rise follows with lower maxima; there is 

 complete recovery in 2k- to 48 hours, A regular fever rhythm 

 appears, usually after the 3rd treatment. Side effects are 

 moderate in degree and, unlike malarial or cabinet therapy, 

 the treatments can be given to patients with serious cardiac 

 lesions without adverse effects. The successive phases of 

 leukocytosis and lymphocytosis resemble those seen in other types 

 of nonspecific therapy, Howie administered pyrifer to 15 patients 

 with advanced general paralysis, all too feeble for malarial 

 therapy. Six were improved, 2 discharged as cured. The average 

 duration of treatment was between 3 and 6 weeks. In schizo- 

 phrenia (15 cases) improvement was seen in 5, The treatment 

 was ineffective for chronic manic states, Pyrifer reduced 

 seizures in one epileptic patient from 32 in 3 weeks to 16 in 

 the same length of time. Nc permanent remission could be 

 obtained . 



218, 



LANPRANCHI, F, 



Ricerche sul plrcgene batterlco : influenza degli amino acid 

 mel mezzi sintetlci, sulla produzione del pirogene (investiga 

 tion on bacterial pyrogens: Influence of synthesis of amino 

 acids In media on pyrogen production) 



