74 



-19 3 4- 



223. WRIGHT, I. S. 



The modern medical treatment of diseases of the peripheral 

 vascular system. 



Med. Clin, No Amer. 17:1429, 1934 



Leukocytosis or immobilization of immune bodies may account 

 for a portion of the benefits secured through the use of 

 'fever therapy' o Vascular changes bring relief from spasm 

 in partially occluded vessels; local capillary dilatation brings 

 an improved blood supply to ulcerated areas and healing is 

 promoted « 



- 1 9 3 5 - 



224o APITZ^ Ko 



Studies on the chemical nature of Shwartzman-active substances 



Jo Immunol. 29:343-358, 1935 



The nucleoproteln fraction of bacteria, obtained by autolysis 

 or extractlonj is Shwartzman-active, The potency is increased 

 in alkaline solutions, A metabolic fraction can be isolated 

 from agar washings through alcohol precipitation; it contains 

 a highly unstable Shwartzman-active fraction, not identical 

 with type-specific carbohydrates. It may be dialyzed slowly 

 from filtered washings but resists tryptic digestion. 



225, DURAN-REifTNALS, F, 



Reaction of spontaneous mouse carcinomas to blood -carried 

 bacterial toxins 



Proc, Soc, Exper, Biol, Med, 32:1517, 1935 



Previous experiments had revealed the insusceptibility of slow- 

 growing malignant carcinomas of the mouse to the tumor-necrotic 

 action of certain bacterial filtrates. Highly toxic agar wash- 

 ings of human typhoid bacilli, of mouse typhoid II and the less 

 toxic filtrates of two other types of mouse typhoid bacilli 

 (I and III) were injected, separately and in combination, in 

 mice bearing mammary carcinomas. 



The highest incidence of local reaction, as well as the most 

 Intense effects, were seen in larger tumors after large doses 



