75 



- 1 9 3 5 - 



of the toxins. Mortality was higher. Partial or total inhibi- 

 tion of tumor growth was higher in the group bearing smaller 

 tumors and receiving smaller doses of the toxins. It is be- 

 lieved that newly formed vessels are most susceptible to toxins. 



226, CECIL, R. L. 



Nonspecific protein therapy. 



J. A.M. A, 105:1846-1854, 1935 



The history of nonspecific protein therapy is reviewed. In- 

 cluded are the following sources of therapeutic preparations: 

 native proteins; serums; protein-split products; enzymes; tissue 

 extracts; bacterial extracts and vaccines. Differences between 

 nonspecific reactions and focal processes are probed. The 

 possibility that all types of 'protein' therapy may be specific 

 in calling forth body defenses is presented. The therapeutic 

 usefulness of leukocytosis is still unexplained. The author 

 notes that gram-negative bacteria and their products cause 

 febrile reactions more often than gram-negative organisms. 

 Application of this type of treatment to specific disease con- 

 ditions is evaluated. 



227, GIEHM, G. 



Die moderne Therapie der Schlzophrenle (Modern therapy of 

 schizophrenia) 



Med. Klin, 31:547-549, 1935 



A suspension of bacterial albumins (pyrlfer) was used in the 

 therapy of schizophrenia. Bacterial proteins from non-pathogens 

 may prove efficacious in selected cases, 



228, HEKTOEN, L. 

 Nonspecific proteins 

 J.A.M,A. 105:1765-1767, 1935 



Foreign proteins united with body fluids are taken up by body 

 cells, particularly those of the reticuloendothelial system; 

 humoral and Intracellular alterations follow. The products 

 of these processes affect the entire organism in a complex 

 fashion. Resultant phenomena are partially temporary in effect, 

 partially permanent. The temporary effect is that exercised 

 on the autonomic or sympathetic nervous system. An increase 



