76 



- 1 9 3 5 - 



in chemical activity accompanies fever. Capillary walls and 

 cells of the reticuloendothelial system are important sites 

 of chemical activity. Proteolytic and lipolytic enzyme output 

 is accelerated. Fibrinogen and complement are decreased 

 initially, then increased. The colloid stability of plasma is 

 lessened. Altered metabolism is shown in the Increased NPN of 

 the blood. Histamine and choline are released as secretory 

 stimulation follows dilatation in the splanchnic area, A local 

 edema may be an outward manifestation of detoxification, 



229. KOPP, I. 



Metabolic rates in therapeutic fever 

 Am, J, Med, Sci, 190:491-49^^ 1935 



Fever was induced by physical means and by mixed typhoid vaccine 

 in 7 patients with neurosyphilis. One patient received fever 

 therapy by all five methods employed. Various combinations 

 of fever production were studied. Metabolic rates at fixed 

 temperature levels were higher during periods of elevation than 

 during periods of falling temperature. Rapidity of fever pro- 

 duction did not affect the results; no differences in basal 

 metabolism could be traced to the technique by which fever was 

 produced , 



230. MENZIES, A. W, C. 



Pyretotherapy in Dementia Praecos 



Lancet 2:99^-996, 1935 



Dmelcos ( Ducrey bacillus atoxic vaccine) intramuscularly or 

 sulfosin produced improvem.ent in 26 schizophrenic patients 

 and a complete remission for four of these. The recovery rate 

 cannot be altered by this type of fever alone; accessibility of 

 the patient to psychiatric treatment was increased and the 

 psychic pattern was broken. 



231, PINKSTON, J. 0. 



Peripheral circulation during experimental fever 



Am. J, Ihysiol, 110:448, 1935 



Sympathectomy delays initial vasoconstriction seen in peripheral 

 vessels following the Injection of typhoid -paratyphoid vaccine. 

 In the normal. Innervated ear of the rabbit, constriction begins 



