78 



- 1 9 3 5 - 



Its volume, and the temperature and pH of the solutions must 

 be considered, pyrogens In water take first rank as causative 

 agents In a reaction. The methods by which Infusion materials 

 may be rendered pyrogen-free are outlined In detail. 



-19 3 6- 



235. ANDERVONT, H. B, 



The reaction of mice and of various mouse tumors to the Injec- 

 tion of bacterial products 



Amo J„ Cancer 27:77-83, 1936 



Bacterial filtrates obtained from meningococcus and B. coll 

 cultures were used to determine their toxicity for mice, using 

 changes In cutaneous tumors as a standard for Judging activity 

 of the filtrates. Toxicity was greater for tumor-bearing mice 

 held at 37° C, than when room temperature was used; the same 

 was true for the normal animal. Normal mice were more resis- 

 tant to toxic filtrates than were the tumor-carrying animals. 

 The route of injection was not Important. Certain stralr dif- 

 ferences In susceptibility to toxic filtrates were shown. 

 Spontaneous mammary carcinomas were resistant to B. coll fil- 

 trates while chemically-induced tumors responded with regression. 



2360 ANDERVONT, H, B. and SHEAR, M.J. 



Production of Shwartzman reaction in rabbits with purified 

 fraction of B, coll filtrate 



Proc, Soc. Exper, Biol, Med, 3^:673, 1936 



The original filtrate and a purified fraction from B. coll were 

 capable of eliciting the Shwartzman reaction and producing tumor 

 hemorrhage in the mouse. The minimal effective tumor-hemorrhage 

 dose of the original filtrate was 0.2 cc . of the 1:50 dilution. 

 When the purified fraction was used, the minimal effective dose 

 for tumor hemorrhage and that eliciting a positive Shwartzman 

 were of the same magnitude. 



237. GENTANNI, E. 



Sulla prezenza di un prlnciplo plrogene e antlpirogene nella 

 cultura batterica (On the presence of a pyrogenlc and antl- 

 pyrogenlc principle in bacterial cultures) 



