80 



-19 3 6- 



241. JACOBI, M, 



The effect of the Shwartzman reaction with bacterigQ. filtrate 

 on transplantable tumors In animals 



Am. J, Cancer. 26:770-774. 1936 



The Shwartzman. phenomenon was provoked in experimental animals 

 bearing mouse sarcoma l80, Plexner-Jobling rat carcinoma. 

 Walker rat carcinosarcoma and Rous chicken sarcoma. Both 

 preparatory and provocative injections of E. typhosa filtrate 

 utilized the undiluted toxin. Preparatory injections were given 

 intratumorally. All tumors responded with violent hemorrhage 

 and necrosis after the provocative Injection, complete sloughing 

 and healing followed In some, slow regrowth of tumor tissue in 

 others. When the injections were made only into tumor tissue or 

 only intraperltoneally, no hemorrhage occurred o 



242. MORGAN^ W. T. J, 



Studies in imraunochemistry, I. The preparation and properties 

 of a specific polysaccharide from B, dysenteriae (Shiga) 



Blochem, J, 30s909-925> 1936 



A polj/saccharide containing 97 per cent reducing sugars on acid 

 hydrolysis was isolated from the 'smooth' form of B. dysenteriae . 

 Strongly dextrorotatory, it contained but 1 per cent of nitrogen, 

 all in the form of acetylated amino groups. It accounts for 

 the serological specificity of the bacterium. The occurrence 

 and significance of certain nonspecific polysaccharides are 

 discussed. 



243. SHEAR, M, J. 



Chemical treatment of tumors, IV. Properties of hemorrhage- 

 producing fraction of B, coll filtrate 



Proc, Soc, Exper, Biol, Med, 34:325-326, 1936 



The hemorrhage-active fraction of B. coll filtrate previously 

 describedwas further purified by methyl alcohol precipitation. 

 The minimum dose for hemorrhagic activity was 0.2 cc, of a 1:500 

 dilution. After solution in water the fraction gave a strongly 

 positive Molisch test and a negative biuret test; it exhibited 

 no selective absorption peak. Activity was demonstrated after 

 storage for 8 weeks in cold temperatures. In biologic tests, 

 normal tissue capillaries were not rendered more permeable 

 after injection of the fraction. 



