85 

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255. GERBER, I, E. and BERNHEIM, A. I. 



Histological studies of tumor reactivity to bacterial filtrates 

 Am. J, Pathol, 13s 67.3, 1937 (Abstract) 



A single intravenous injection of 20 to 100 reacting units of 

 meningococcus 'agar-washing' filtrate produced severe degenera- 

 ti\.'e changes in sarcoma l80 of the mouse., Vascular engorge- 

 ment, edema and necrosis of the tumor cells preceded regression 

 (or regrowth) of the tumor. Hemorrhage was seen in the early 

 stages of chang-e and vessel lesions and thrombi were absent^ 

 The filtrate appeared to affect tumor cells directly. The 

 reaction "is analogous to and Is elicited by the bacterial 

 active principles of the Shwartzman phenomenon". No prepa^'a- 

 tory local injection was required. 



256. HJORTH, P. 



Investigations of a thermostable bactericidal substance in 

 human serum, demonstrated particularly in the serum of fever 

 patients 



Acta Path, et mlcrobiol, scand, 14 s 412-426, I937 



The serum of patients with febrile conditions contains the 

 thermostable, bactericidal substance previously described by 

 Wulff(J, Immunol, 27^451, 1934, Fever alone does not lnf'lu^'n<^« 

 production of the bactericide. In undulant fever and influen- 

 zal pneumonia, the sera were not bactericidal, whereas Inacti- 

 vated sera from patients with cancer, cirrhosis and nephritis. 

 In which temperatures were normal or only slightly iP'-reased, 

 were high potent. This substance was active against meningococd. , 

 gonococcl, and gram-negative cocci; Staph ylococcus aureus 

 growth was not inhibited. The serum~^idnot Iose~poiiFcy com- 

 pletely until after exposure for one-half hour to 68° G. 

 Minute amounts of active serum restored bactericidal effec- 

 tiveness. The properties of the substance resemble those cre- 

 dited to beta-lys.tn by Petterson (Microben. (Jena), 1934). 



257. MILLER, P, R. 



The induced development and histogenesis of plasma cells 

 J. Exper, Med, 645 333-347, 1937 



The mechanism by which the injection of tuberculoprot^in stimu- 

 lates plasma cells after Intravenous or intraperitoneal injec- 

 tion was studied at length. Plasma cells were found in normal 

 connective tissue. Genesis proceeds, it is believed, in lympho- 

 cytes or mesenchymal cells. The Russell body cells constitute 



