86 



- 1 9 3 7 - 



the end point in the evolution of these cells. The greatest 

 concentration was found in those organs closely concerned 

 with detoxification, as the omentum and lymph nodes parti- 

 cularly after the injection of bacterial proteins „ They are 

 noted in spleen, liver, the body wall of the cecum, Polyblasts 

 in the 'milkspots' of the omentum were precursors of these 

 cells. 



258. OLITZKI, L. and AVINERI-SHAPIRO, So 



The hypothermic factor of B, dysenteriae Shiga 



J, Exper. Path. l8:3l6-321, 1937 



In B. dysenteriae Shiga , and in other organisms, a hypothermic 

 fraction may exist. Hyperthermic reactions may precede and 

 follow the drop in temperature. The lipoid and carbohydrate 

 fractions of the organism considered in this study produced 

 temperature increases only; the hypothermic activity was closely 

 associated with the protein f inaction which may produce hyper- 

 glycemia and leucopenia. 



259. OLITZKI5 L., LEIBOWITZ, J. and BERMAN, M. 



Further investigations on the chero.lstry, toxicity and other bio- 

 logical properties of different fractions of dysentery bacteria 



Brit, J. Exper. Path, lS:305-3l6, 1937 



Bacterial antigens, on injection, have the ability to produce 

 hyperglycem.ia combined with a fall of inorganic blood phos- 

 phorus and followed by hypoglycem-ia and rising phosphorus 

 index. The relationships of these alterations to the rise and 

 fall of leukocytes were determined , Fractions obtained from 

 Bo dysenteriae Shiga , Flexner , and Y (fractions of Purth and 

 Landsteiner) as well as the hapten were injected intravenously 

 in test animals. Blood sugar and leoKocytes were examined. 

 Changes in body weight were recorded. Toxic symptoms were ob- 

 served, A leucopenic factor was present in PI and P2 fractions; 

 a slight leucopenic effect was observed after administration 

 of the C fraction. The hapten did not effect leukocytes. In 

 PI, C and the hapten a glycemlc factor occurs; It was present 

 in unpurified polysaccharide 2 but not in the residue after 

 alcohol extraction, P2 was strongly toxic, but fraction C and 

 the hapten were non-toxic. The glycogen in liver tissue, gal- 

 actose tolerance and diastase in blood were altered during the 

 hyperglycemic reaction. Spleen and bone marrow changes took 

 place during the period of leukopenia. Antileucopenic and 

 anti-glycemic immunity existed independently. 



