90 



-19 3 8- 



depresses leukocyte genesis and produces a leukopenia. Both 

 pyrifer and nucleic acid stimulate leukocyte production. 



270. RANSOM, S. W. JR. 



Fever Induced by the intravenous injection of typhoid -paratyphoid 

 vaccine 



Arch. Int. Med. 61:285-296, 1938 



The reaction of the normal cat to Intravenous typhoid -para- 

 typhoid vaccine, is one of cyclic stimulation, first, heat con- 

 servation, sympathetic stimulation and heat production and, 

 secondly, a period of heat loss and parasympathetic stimula- 

 tion. The cycle of these alternate reactions is repeated 

 three times. The heat preservation mechanism predominates, 

 and the end result appears to be sustained hyperthermia. 

 Anaesthesia appears to affect either the mechanism of heat 

 preservation and loss or a coordinating control of these 

 phenomena; etherization of cats before vaccine injection re- 

 sults in hypothermia and parasympathetic response to the 

 bacterial material. In typhoid fever. Intravenous typhoid 

 vaccine brings forward similar mechanisms. 



271. ROBERTSON, R. C. and YU, H 



Leukopenia and the toxic substances of B. typhosus 

 J. Hyg. 38:299, 1938 



The intraperitoneal or intravenous Injection of toxic fil- 

 trates from several strains of E. typhosa provoked, in the 

 rabbit given sublethal doses, sharp leukopenia . The leuko- 

 cytosis which followed persists two days. In vitro mixtures 

 of the filtrate and blood produced no pronounced leukocyte 

 changes. Histologic section? from lung, liver, spleen and 

 bone marrow displayed an accumulation of neutrophils in these 

 organs . 



The constant liberation of toxic substances in human typhoid 

 fever is believed to be responsible for the leukopenic response, 



