- 1 9 3 9 - 



27^. ANDERSON, C. G., HAWORTH, W. N., RAISTRICK, H. and STAGEY, M, 



Polysaccharide synthesized by microorganisms. IV. The molecular 

 content of luteose 



Biochem. J. 33;272-279^ 1939 



Luteose, a neutral polysaccharide remaining after removal of the 

 malonic acid content of luteic acid, is composed of beta-glucose 

 units linked through the 1,6-posltions. The molecular structure 

 may be of the closed-chain type. Luteic acid fe a metabolic pro- 

 duct of penicillin luteum (Zukal), 



275. ANDERVONT, H, B, and SHIMKIN, M. Bo 



The effect of ascorbic acid upon the hemorrhage produced by bac- 

 terial filtrate in transplanted tumors 



Am. J. Cancer 362 451-^59* 1939 



Minute intraperitoneal injections of a bacterial filtrate of B. 

 prodigiosus into tumor-bearing mice (Sarcoma #37) were followed 

 by intracutaneous injections of neutralized or unneutralized 

 ascorbic acid. Similar experiments tested the effects of ascor- 

 bic acid and bacterial filtrate in combination against Sarcoma 

 180 and Lung Tumor F transplants. Ascorbic acid prevented the 

 appearance of hemorrhage and regression of tumors after injection 

 of the filtrate from Bo prodigiosus . Acidity was unrelated to 

 hemorrhage prevention, but reducing power of ascorbic acid was 

 apparently involved in the phenomenon » Hemorrhage Inhibition was 

 directly proportional to the amounts of filtrate and ascorbic 

 acid used. The route of administration appeared to be unimportant 

 A theory is advanced that the bacterial filtrate may produce 

 hemorrhage in tumor tissue through sudden lowering of tumor as- 

 corbic acid content, thus weakening the capillaries and permitting 

 hemorrhagic extravasation. 



276. GO TUI, BENAGLIA, A. E., RUGGIERO, W„ F, and YATES, A. L. 



Study of the fever -producing principle in the typhoid vaccine 



Proc. Soc. Expero Biol. & Med. 41:272-275^ 1939 



There is a close relationship between the fever-producing sub- 

 stance found in vaccines from B. typhosus cultures and pyrogens 

 isolated from contaminated waters" and Infusion solutions. Initial 

 leukopenia, rise in temperature and chills are identical; either 

 may produce transient gastrointestinal disturbances. 



