97 



- 1 9 3 9 - 



Extracts from the cappola strain of the typhoid bacillus were 

 injected intravenously in the rabbit in dosages ranging from 

 sublethal to highly toxic amounts. Single and repeated in- 

 jections were administered; the extract was also prepared with 

 fresh normal, inactivated normal and immune serums. The severe 

 systemic reactions, extreme leucopenia and tendency toward pro- 

 longed coagulation time were observed after typhoid extract 

 administration. The systemic reactions were dependent upon the 

 dose and independent of the dose for blood changes. The systemic 

 effects appear to become less intense after repeated injection; 

 no complete immunity could be demonstrated, and the changes 

 in blood cellular components were not effected. Mixtures of 

 ' serum and toxic typhoid extract produced symptoms characteristic 

 of small sublethal doses of the extract when given alone. 



291. SMITH, H. W. 



Physiology of the renal circulation 



The Harvey Lecture Series 35:200-203, 1939-19^0 



In a review of known facts on renal circulation, it is stated 

 that the only known method of inducing renal hyperemia is by the 

 use of pyrogens "either as present in typhoid vaccine or in pyro- 

 genic inulin," Hyperemia is manifest at the time of the chill 

 phase and continues for several hours. The relative increase 

 depends upon the control level and is ".,,in general.,, from 36 

 to 60 per cent above the control levels''. Antipyretics have little 

 influence. The dilatation is centered in the efferent arteriole; 

 the filtration fraction is decreased, but the rate of filtration 

 is essentially unchanged. 



292. TERRY, G. G, 

 Fever and Psychose s 



New York: Paul B. Hoeber, Inc., 1939 



Biologically induced fever (through the use of organic, bacterial 

 and "foreign" agents) produces some evidence of improvement in 

 manic-depressive states, but only a few benefits in schizo- 

 phrenics. 



It has been stated that Coley's fluid has therapeutic usefulness 

 in the manic-depressive states, 



293. WALKER, E. L. and HANDMAN, M. S. 



Biological reactions of malignant neoplasms. I. The reaction 

 to bacterial fractions 



