99 

 -19^0- 



294. ANDERVONT^ H. Bo 



Effect of colchicine and bacterial products on transplantable 

 and spontaneous tumors in mice 



J. Nat, Cancer Inst.^ 1^361-6^ 1940 



This study was undertaken to compare the effects of bacterial 

 products and colchicine in inducing tumor hemorrhage and 

 affecting tumor growth. Young mice bearing either Sarcoma 37 

 or Carcinoma P as transplantable tumors or mammary carcinoma 

 as a spontaneous tumor, were given colchicine solutions or 

 B. coll filtrate, in varying dosages, intraperitoneally. The 

 effective dose which elicited tumor -hemorrhage without killing 

 the animals was determined by injection of single doses at various 

 levels of potency. Injections of colchicine in varying doses were 

 repeated at differing time intervals. In order to determine 

 whether or not colchicine and filtrate have a supplementary effect 

 on each other, separate injections were made of each substance 

 at practically the same time. 



The effective dose of colchicine, 0.1 mg. was close to the lethal 

 dose and was no more effective than bacterial filtrate which has 

 a much wider range of potency. Repeated injections of colchicine 

 In doses too small to elicit tumor hemorrhage had no Influence 

 on tumor growth; while injections of hemorrhage-producing doses were 

 toxic to the majority of animals. Both substances were supplemen- 

 tary to each other In eliciting hemorrhage In transplanted tumors, 

 but their combined action was no more effective than either alone 

 In treatment of spontaneous tumors. Tumor P, after the 17th 

 serial passage, became susceptible to hemorrhage Induction by 

 bacterial filtrate. 



5. ASHENBURG, N. J., SANDHOLZER, L, A,, SCHERP, H, W. and BERRY, 3. P. 



The influence of bacterial and nonbacterial polysaccharide upon 

 bacterlophagy 



J. Bact., 39s71-72, 194o 



In an investigation of the effect of capsular polysaccharide (from 

 Aerobacter) upon the activity of a bacteriophage to which strains 

 of Aerobacter are susceptible, inhibition of lysis was noted. 

 Non-bacterial polysaccharide (starch glycogen and gum arable), and 

 polysaccharide from a bacteriophage-resistant strain inhibited 

 lysis to an equivalent degree. "The results did not support the 

 hypothesis that susceptibility to bacterlophagy depends upon 

 immunological specificity," 



