100 



- 1 9 4 - 



296. BEESON^ Po Bo and HOAGLAND, C„ Lo 



The use of calcium chloride in the treatment of chills 



N. Yo State J. Med. 40r803-804^ 1940 



Intravenous administration of calcium chloride in humans aborts 

 the chills due to malaria, blood transfusions, and typhoid vaccine. 

 Relief of the typhoid chill appeared to have no effect on the sub- 

 sequent elevation of the body temperature. 



297. CAMERON, G». R., DELAPIELD, M. E. -and WIISOII, J. 



Pathological changes produced in rats and mice by a toxic fraction 

 derived from Bacterium typhimuriuffl ■ 



J. Pathc Bacto 51s 223-233^ 19^+0 



. A non-dialyzable protein-polysaccharide fraction from B. typhi - 

 . murium ' was injected intrapei^itoneally, in doses ranging from 

 O.O5-I0O mgc into 95 mice and 54 albino rats. The animals were 

 sacrifleed at | hour to 6 days following injection, and various 

 tissues were stained for microscopic study. Forty mice were 

 injected with living B. typh imurium and their livers examined 

 microscopically at in¥ervaTs^ varying from 1922 days following 

 the initial injection. Blood sugar and hepatic glycogen content 

 were also determined in animals injected . with the bacterial 

 fraction. 



. A profound disturbance of the carbohydrate metabolism was shown 

 by the histological and chemical results. The liver showed marked 

 portal congestion associated with hemorrhage, thrombosis, and ., 

 necrosis; the spleen and lymph glands exhibited necrosis of 

 Malpighian bodies and lymphoid follicles. Infection of the 

 animals with living B. typhimurium produced similar resiilts of 

 more severe degree. 



■■ Liver glycogen in rats and mice, and blood sugar in mice were 

 rapidly <3ecreased in amount following initial injection. Carbo- 

 hydrate disturbances are primarily of hepatic origin. 



298. CENTANNI, E. 



Weitere Beitrage zur Kenntnis des pyrogenen Wlrkstoffs des _/>.\-; 

 ; Fiebers (Further studies toward knowledge of active pyrogenic 

 > materials of fever) 



I Deutsch. med. Wchnschr. (Anal. Series) 10; 263-265, 1940 



The chemical character of the pyrogenic active material formed in 

 the decomposition of bacteria was studied. It is reported that 



