107 



-19^0- 



314. WALTER, C. W. 



The relation of proper preparation of solutions for intravenous 

 therapy to febrile reactions 



Ann. Surg. 112:603-625, 1940 



While the bacterial pyrogens of water, apparatus and rubber tub- 

 ing are believed to be the principal causes of febrile reactions 

 during intravenous therapy, in dextrose solution the dehydration 

 products should also be eliminated if possible. Such products of 

 molecular interaction include hydroxymethylf urf ural and levulinic 

 acid. The alkaline film following sterilization of soft glass 

 may cause some polymerization of dextrose during sterilization. 

 The intravenous kit itself should be carefully sterilized if re-use 

 contemplated . 



