108 



-19^1 



315. ABERNATHY, T. J. and AVERY, Oo T. 



The occurrence during acute Infections of a protein not 

 normally present in the blood. I, Distribution of the reactive 

 protein in patients' sera, and the effect of calcium on 

 flocculation reaction with C polysaccharide of Pneumococcus 



J. Exper. Med. 73; 173-182, 1941 



Sera obtained from both humans and monkeys during acute in- 

 fections contained a protein which was precipitated by the 

 C polysaccharide of pneumococci. C-precipitable substance 

 was Inactivated by exposure to temperatures above 63^ C, or 

 the range of temperatures in which protein is denatured. After 

 ammonium sulfate separation, the reactive material was found 

 in the albumin fraction. Decalcification by additions of 

 potassium oxalate and sodium citrate inhibited precipitation 

 from reactive serum; the inactivation is reversible through 

 the addition of minute amounts of Ca, The reactive protein 

 is non-specific with respect to the inciting cause of the 

 infection, 



316. DELATMAY, A., LEHOULT, Y., and SARCIRON, R. 



Recherches sur le chlmiotactlsme leueocytaire,pouvoir chimi- 

 tactique des antigenes glucido-lipidiques (Investigations on the 

 chemotaxis of leukocytes. The chemotactic power of glucido- 

 lipoid antigens) 



Compt. rend. Soc. blol. 13521529-3532, 19^1 



Autolyzed typhoid bacilli, in suspensions diluted from 1:10 

 to 1:1000, were injected in the guinea pig. Each of the 4 doses 

 given contained 0.5 cc. of the diluted suspension. Microscopic 

 examination of the injected tissue showed an Invasion of neutro- 

 phils disseminated in the hypodermls. When the glucido- 

 lipoid antigen of the typhoid bacillus was injected alone, it 

 consistently produced the leukocyte migration, and antigens 

 of a number of other bacteria (E. coll , the Flexner , para - 

 t yphoid B. and Slajte a organisms) have identical activity. 

 Maxima for leukocyre migration lie between 1:100 and 1:1000 

 dilutions and stronger doses have lower chemotactic power. 

 The importance of the colloid structure in immunology is 

 emphasized . 



%■ 



