114 



-19 4 1- 



330. SHEAR, M. J« 



Effect of a concentrate from B. prod igio sua filtrate on subcu- 

 taneous primary Induced mouse tumors 



Cancer Res. 1:731# 19^1 



A nitrogen -containing polysaccharide, obtained as a concen- 

 trate from broth cultures of B, orodliziosua . was injected In mice 

 bearing primary chemically-induced tumors. Doses more than 

 500 times the minimum hemorrhage -producing dose -wtr* lethal 

 for most of the tumor-bearing straing^but normal mice tolera- 

 ted even larger doses » Severe hemorrhage was produced in a few 

 hours in the primary spindle cell sarcoma, but regrowth was 

 commonly seen. Mice with larger tumors usually succumbed to 

 a given dose while those with small tumors survived. Repeated 

 injections of gradually-increased small doses of the poly- 

 saccharide produced tolerance to the lethal effect, but lethal- 

 ity was always more pronounced for the tumor-bearing mouse. 



331. WBISBEaG, Jo and GOLDSTEIN, H. H. 



Modification of the use of 1;yp^d vaccine in the production 

 of hyperpyrexia 



Illinois M, I^ 79:139-140, 1941 



The authors devised an expanding doaige method for the pro- 

 duction of therapeutic hyperpyrexia. Typhoid vaccine was ad- 

 ministered in a low initial dose until fever was produced; 

 at the height of fever, a second larger dose was injected. 

 Very high temperatures were secured by this method. A definite 

 dosage schedule is appended to the article, 



332. WIENER, A. S. DREMLAND, B. H., HYMAN, M. A. and SAMWICK, A. A. 



Transfusion reactions. Experience with more than 3000 blood 

 ^ansfusions 



Am. J. Clin. Path. 11:102-121, 1941 



In 1936, the incidence of chills and fever appearing after blood 

 transfusion was 12 per cent, on the average, regardless of the 

 method employed in transfusion. When the saline solution used 

 was exchanged for another type, reactions dropped to 3.8 per 

 cent and has continued to be between f and 3 per cent. 



